Frequency of deletion formation decreases exponentially with distance between short direct repeats
- 1 May 1994
- journal article
- Published by Wiley in Molecular Microbiology
- Vol. 12 (4) , 561-569
- https://doi.org/10.1111/j.1365-2958.1994.tb01042.x
Abstract
The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000-fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA-duplex flexibility. A similar relationship between deletion formation and distance was observed in a θ-replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.Keywords
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