Effect of Mannitol on the Kidney

Publisher Website
Google Scholar
Abstract
THE use of hypertonic mannitol as an osmotic diuretic has captured the attention and imagination of investigators and clinicians alike in the past several years. First used widely by physiologists to promote urine flow during studies of general renal physiology, it was reported in 1945 by Selkurt1 to improve renal function in a dog's kidney after a period of ischemia. This study led to the use of mannitol in clinical situations involving a decrease in renal blood flow or the presence of circulating nephrotoxic substances.2,3 The result of this interest has led to significant investigation of the renal, as . . .