Uterine Activity in Diabetes Insipidus

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Abstract
In 2 nonpregnant women with cranial diabetes insipidus, myometrial activity under different hormonal conditions was studied by intrauterine pressure recording. Recordings were performed when the women were under the influence of their regular treatment with des-aminocys1-D-arg8-vasopressin (DDAVP) and when they had fully developed symptoms of their disease. Uterine activity was similar to that found in normal women under the same hormonal conditions and generally did not change when symptoms of lack of vasopressin appeared. Both DDAVP (15-20 .mu.g) given intranasally and lysine vasopressin (0.2 IU) given i.v. stimulated uterine activity, particularly in late secretory menstrual phase. Apparently endogenous vasopressin is of minor importance for induction of spontaneous uterine activity in nonpregnant women.

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