Single-Dose Pharmacokinetics of Amprenavir Coadministered with Grapefruit Juice
Open Access
- 1 May 2002
- journal article
- clinical trial
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (5) , 1589-1590
- https://doi.org/10.1128/aac.46.5.1589-1590.2002
Abstract
In this crossover study in 12 healthy volunteers, coadministration of amprenavir (1,200 mg; single dose) with grapefruit juice slightly reduced the maximum concentration of drug in serum ( C max ) compared to administration with water (7.11 versus 9.10 μg/ml), slightly increased the time to C max (1.13 versus 0.75 h), and did not affect the area under the concentration-time curve from 0 to 12 h (AUC 0-12 ), the AUC 0-∞ , or the concentration at 12 h. Therefore, grapefruit juice does not clinically significantly affect amprenavir pharmacokinetics.Keywords
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