Advances in the immunobiology of the skin. Implications for cutaneous malignancies
Open Access
- 1 January 1986
- journal article
- review article
- Published by Springer Nature in Cancer and Metastasis Reviews
- Vol. 5 (2) , 167-178
- https://doi.org/10.1007/bf00046429
Abstract
Recent advances in cutaneous immunobiology have led to the realization that skin is an important and unique immunologic organ. Studies on the immunobiology of skin cancers induced by ultraviolet radiation indicate that immune mechanisms can play a crucial role in the development of cutaneous tumors. This paper summarizes the evidence linking skin and the immune system and discusses current hypotheses concerning the mechanisms by which UV radiation interferes with cutaneous immunity. The significance of these findings for cutaneous carcinogenesis is discussed.Keywords
This publication has 92 references indexed in Scilit:
- Studies on the Mechanism of Systemic Suppression of Contact Hypersensitivity by UVB Radiation. II. Differences in the Suppression of Delayed and Contact Hypersensitivity in MiceJournal of Investigative Dermatology, 1986
- Sun and malignant melanomaJournal of the American Academy of Dermatology, 1984
- Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon.The Journal of Experimental Medicine, 1984
- Local immune response in basal cell carcinoma: Characterization by transmission electron microscopy and monoclonal anti-T6 antibodyJournal of the American Academy of Dermatology, 1983
- Suppressor T Lymphocytes Control the Development of Primary Skin Cancers in Ultraviolet-Irradiated MiceScience, 1982
- SUPPRESSION OF CONTACT HYPERSENSITIVITY BY UV RADIATION AND ITS RELATIONSHIP TO UV-INDUCED SUPPRESSION OF TUMOR IMMUNITYPhotochemistry and Photobiology, 1981
- Epidermal Langerhans cells are derived from cells originating in bone marrowNature, 1979
- THE FUNCTIONS OF THE THYMUS SYSTEM AND THE BURSA SYSTEM IN THE CHICKENThe Journal of Experimental Medicine, 1966
- The Effect of Ultraviolet Radiation on Experimental Cutaneous Sensitization in Guinea-Pigs**From the Department of Dermatology and the Kettering Laboratory, College of Medicine, University of Cincinnati, Cincinnati, Ohio.Journal of Investigative Dermatology, 1963
- The Croonian Lecture: The homograft reactionProceedings of the Royal Society of London. B. Biological Sciences, 1958