Cognitive Function in Children and Subsequent Type 2 Diabetes
Open Access
- 1 March 2008
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 31 (3) , 514-516
- https://doi.org/10.2337/dc07-1399
Abstract
OBJECTIVE—To assess whether a diagnosis of type 2 diabetes by age 42 years is associated with prior cognitive deficits in childhood. RESEARCH DESIGN AND METHODS—Logistic regression estimated type 2 diabetes risk among 9,113 members of the 1958 British birth cohort of the National Child Development Study (NCDS). Associations with type 2 diabetes were estimated for general ability and reading comprehension assessments at age 11 years, modeled using SD units. Adjustment was for markers of early-life exposures, social and material family characteristics, sex, and disability, with further adjustment for BMI at age 7 years. RESULTS—Adjusted odds ratios (95% CIs) for type 2 diabetes (n = 69) are 0.67 (0.51–0.87) for general ability and 0.58 (0.44–0.77) for reading comprehension. Neither additional adjustment for BMI, nor limiting the definition of type 2 diabetes to onset after age 33 years altered the associations substantially. CONCLUSIONS—Impaired cognitive function may precede clinical onset of type 2 diabetes.Keywords
This publication has 10 references indexed in Scilit:
- Cognitive Function in Children and Subsequent Type 2 DiabetesDiabetes Care, 2008
- Cognitive Function in Children and Subsequent Type 2 DiabetesDiabetes Care, 2008
- High-fat diets, insulin resistance and declining cognitive functionNeurobiology of Aging, 2005
- Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?Biochemical Society Transactions, 2005
- Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?Biochemical Society Transactions, 2005
- The Relationship between Impaired Glucose Tolerance, Type 2 Diabetes, and Cognitive FunctionJournal of Clinical and Experimental Neuropsychology, 2004
- Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohortBMJ, 2002
- Predictors of change in the neuropsychological profiles of children with type 1 diabetes 2 years after disease onset.Diabetes Care, 1999
- Emerging epidemic of type 2 diabetes in youth.Diabetes Care, 1999
- Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studiesDiabetes Care, 1997