DNA content and enzymic activities in the auditory regions of seizuresusceptible and non-susceptible strains of mice

Publisher Website
Google Scholar
Abstract
The developmental profiles of four glycosidase enzymes (β-D-glucosidase, β-D-glucuronidase, β-D-N-acetylglucosaminidase and β-D-galactosidase) in the cochleas, cochlear nuclei and inferior colliculi of four strains of mice were investigated. The strains used were an audiogenically seizure-susceptible strain (DBA/2) and three non-susceptible strains (BALB/c, C3H/He and Swiss/A2G). The enzymic activities fell to varying degrees from 7 to 28 days of age. Two significant observations were made—β-D-glucuronidase was low in the regions of the C3H/He strain, and β-D-galactosidase was particularly low in the regions of the DBA/2 strain. The very low activity of β-D-galactosidase in the DBA/2 mice is discussed in relation to the ganglioside patterns known to be present in these seizure-susceptible mice. Studies on the DNA contents of these auditory regions in the four strains showed no correlation with seizure sensitivity.