Recurrent idiopathic anaphylaxis

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Abstract
Patients (18) with recurrent episodes of life-threatening anaphylaxis of unknown cause were studied. Each patient had repeated detailed histories taken and had repeated physical examinations, hypersensitivity skin tests to foods and complete blood cell counts. Each patient underwent stringent dietary manipulation. Of the 18 patients, 17 underwent a series of studies. Three patients were hospitalized. Results of all tests were essentially normal except for an elevated plasma histamine level during attacks in 2 patients. Episodes could not be prevented with antihistamine therapy. Attacks were treated successfully by instructing the patients in the self-administration of epinephrine. Recurrent episodes of anaphylaxis due to non-immunologic histamine release apparently can occur without discernible cause and can be life-threatening.

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