Syntheses of Pyrroloquinoline Quinone Derivatives: Model Compounds of a Novel Coenzyme PQQ (Methoxatin)
- 1 January 1987
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1987 (12) , 1067-1071
- https://doi.org/10.1055/s-1987-28172
Abstract
Pyrroloquinoline quinone derivatives were synthesized as model compounds of a novel coenzyme PQQ. The 2-mono- and 2,9-dicarboxylic acid derivatives 1b and 1d and the 1-methylated derivative If were synthesized relatively easily from the intermediates 5 and 4 of the PQQ-synthesis. The 2, 7-dicarboxylic acid derivative 1e was also synthesized via a combination of the Japp-Klingemann reaction and Fischer indolization.Keywords
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