Effect of Thyroid Hormones on the Prolactin Response to Thyrotropin-Releasing Hormone in Normal Persons and Euthyroid Goitrous Patients*
- 1 August 1978
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 47 (2) , 275-279
- https://doi.org/10.1210/jcem-47-2-275
Abstract
In nine euthyroid goitrous patients, increasing doses of T4 caused a significant decrease in the PRL response to TRH; the PRL response fell significantly at a dose of T4 of 100 μg/day for 1 month (P < 0.02) and fell further with increasing doses so that at 300 ng T4/day, the PRL response was 40% of that in the untreated state. T4 treatment also blunted the PRL response to chlorpromazine (P < 0.05) in a separate group of euthyroid goitrous patients. In contrast, there was only a small drop of the PRL response to TRH in normal subjects treated with T4 (n = 9) and none at all with T3 (n = 7). These data, together with previously published reports, suggest that thyroid hormone may affect PRL secretion in the presence of thyroid disease (hyperthyroidism, hypothyroidism, or euthyroid goiter), but that physiological amounts of thyroid hormone have little or no modulating effect on PRL secretion in normal persons.Keywords
This publication has 1 reference indexed in Scilit:
- The Comparative Effect of T4and T3on the TSH Response to TRH in Young Adult MenJournal of Clinical Endocrinology & Metabolism, 1977