Oncogenicity of simian virus 40 deletion mutants that induce altered 17-kilodalton t-proteins.
- 1 September 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (9) , 4299-4302
- https://doi.org/10.1073/pnas.76.9.4299
Abstract
Plaque-purified viable SV-40 deletion mutants containing deletions between map positions 0.54-0.59 induced tumors in 21-92% of LSH hamsters inoculated during the first 24 h of life. HinfI restriction endonuclease digestion patterns of the genomes of virions rescued from the tumor [African green monkey kidney CV-1] cells and the distribution of SV-40 early proteins in these cells associated tumor induction with the inoculated mutants. The DNA sequences comprising that portion of the early SV-40 genome between map positions 0.54-0.59 are not essential for SV-40 oncogenicity.This publication has 21 references indexed in Scilit:
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