A Platelet Defect in a Patient with Eosinophilic Leukaemia: Absent Ristocetin-Induced Platelet Aggregation Associated with a Reduced Platelet Sialic Acid Content

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Abstract
Platelets from a patient with eosinophilic leukemia were not aggregated by ristocetin. The defect was not corrected by normal human plasma and was due to a platelet abnormality. The patient''s platelets showed a diminished sensitivity to aggregation by bovine factor VIIIVWF. The defect was not associated with a prolonged bleeding time. No abnormalities were detected in ADP, collagen or thrombin-induced platelet aggregation. Biochemical studies showed that the platelets were deficient in sialic acid. This deficiency was associated with a reduced staining for glycoprotein I following SDS[sodium dodecyl sulfate]-polyacrylamide gel electrophoresis. An acquired platelet surface abnormality is suggested.