THE EXCRETION OF INTRAVENOUSLY ADMINISTERED SALINE BY THE RAT

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Abstract
A study was made of the excretion of Na and water by unanesthetized rats to which hypo-, iso-, and hyper-tonic saline was given by means of an external jugular vein cannula. Renal tubular re-absorption of Na and water decreased after 77, 154 or 308 m[image] saline were given. 1740 m[image] saline decreased the reabsorption of Na but not that of water. These changes bore no consistent relationship to any increase of glomeruler filtration rate. Pitressin did not increase renal Na excretion or reduce renal tubular reabsorption. Desoxycorticosterone glycoside, given after or during the saline infusion reduced renal Na excretion, but not to the normal values. Tubular Na reabsorption was also restored to normal. These renal responses were not explicable in terms of osmoreceptor-posterior pituitary activity alone, of antidiuretic hormone-adrenal antagonism, or decreased output of adrenal steroids. No physiological pathway could be proposed although it was suggested that changes of body fluid as well as changes in concentration might be responsible.

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