Absorption and Excretion of Sulfamethyldiazine (2-Sulfanilamido-4-methyl-pyrimidine) in Human Subjects

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Abstract
After a single 5 g oral dose of sulfamethyldiazine, the blood levels rise much more rapidly, higher levels are attained, and these are sustained longer than after a similar amount of sulfadiazine. The monomethyl compound was excreted more completely in the urine than sulfadiazine, but a larger proportion of the former was found in the conjugated (3 acetylated) form. Sulfamethyldiazine warrants a clinical trial with doses that are smaller than those customarily used. Particular attention, however, should be paid to the possibility of renal or nerve damage in cases in which prolonged treatment with the drug is contemplated.

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