The diverse and pervasive chemistries of the α-keto acid dependent enzymes
- 13 April 2007
- journal article
- review article
- Published by Springer Nature in JBIC Journal of Biological Inorganic Chemistry
- Vol. 12 (5) , 587-601
- https://doi.org/10.1007/s00775-007-0231-0
Abstract
The number of identified and confirmed α-keto acid dependent oxygenases is increasing rapidly. All of these enzymes have a relatively simple liganding arrangement for a single ferrous ion but collectively conduct a highly diverse set of chemistries. While hydroxylations and a variety of oxidation reactions have been most commonly observed, new reactions involving dealkylations, epimerizations and halogenations have recently been discovered. In this minireview we present what is known of the α-keto acid dependent enzymes and offer an argument that the chemistry that is unique to each enzyme occurs only after the production of a pivotal ferryl-oxo intermediate.Keywords
This publication has 111 references indexed in Scilit:
- Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylaseProceedings of the National Academy of Sciences, 2006
- Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymesProceedings of the National Academy of Sciences, 2006
- Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damageThe EMBO Journal, 2006
- Free radicals, metals and antioxidants in oxidative stress-induced cancerChemico-Biological Interactions, 2006
- Aberrant activity of the DNA repair enzyme AlkBJournal of Inorganic Biochemistry, 2004
- Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related EnzymesCritical Reviews in Biochemistry and Molecular Biology, 2004
- O2- and α-Ketoglutarate-Dependent Tyrosyl Radical Formation in TauD, an α-Keto Acid-Dependent Non-Heme Iron DioxygenaseBiochemistry, 2003
- Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)Journal of Molecular Biology, 2001
- Studies on the active site of deacetoxycephalosporin C synthaseJournal of Molecular Biology, 1999
- Heme-Containing OxygenasesChemical Reviews, 1996