Anesthetics and Pressure Reversal of Anesthesia

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Abstract
General and local anesthetics may have a common hydrophobic site of action in biologic membranes. High atmospheric pressure restored the depression of the compound action potential produced by local anesthetics. The dominant membrane action of anesthetics apparently is to expand membrane proteins. The overall expansion of the excitable membrane by the anesthetic and the amount of recompression by high pressure, is made up of different contributions from membrane proteins, lipids and water. The recompression events at high pressure are shown.