Activity of SCH 66336, a tricyclic farnesyltransferase inhibitor, against human tumor colony-forming units
Open Access
- 1 April 1999
- journal article
- research article
- Published by Elsevier
- Vol. 10 (4) , 449-453
- https://doi.org/10.1023/a:1008313232381
Abstract
No abstract availableKeywords
This publication has 19 references indexed in Scilit:
- Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor CompoundsJournal of Medicinal Chemistry, 1997
- Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylationBioorganic & Medicinal Chemistry, 1997
- Novel Tricyclic Inhibitors of Farnesyl Protein TransferasePublished by Elsevier ,1995
- Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeuticCell, 1994
- Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.Proceedings of the National Academy of Sciences, 1992
- Ras C-terminal processing enzymes—New drug targets?Cell, 1991
- All ras proteins are polyisoprenylated but only some are palmitoylatedCell, 1989
- The ras gene family and human carcinogenesisMutation Research/Reviews in Genetic Toxicology, 1988
- ras GENESAnnual Review of Biochemistry, 1987
- Primary Bioassay of Human Tumor Stem CellsScience, 1977