Evidence for extrinsic exonucleolytic proofreading.
Open Access
- 20 April 2006
- journal article
- Published by Taylor & Francis in Cell Cycle
- Vol. 5 (9) , 958-962
- https://doi.org/10.4161/cc.5.9.2736
Abstract
Exonucleolytic proofreading of DNA synthesis errors is one of the major determinants ofgenome stability. However, many DNA transactions that contribute to genome stability requiresynthesis by polymerases that naturally lack intrinsic 3´ exonuclease activity and some of whichare highly inaccurate. Here we discuss evidence that errors made by these polymerases may beedited by a separate 3´ exonuclease, and we consider how such extrinsic proofreading may differfrom proofreading by exonucleases that are intrinsic to replicative DNA polymerases.Keywords
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