STUDIES ON THE PARATHYROIDS IN ALLOXAN DIABETIC RATS

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Abstract
The parathyroids were studied in rats with uncontrolled alloxan diabetes of about 14 days duration unaccompanied by ketonuria. The diabetic rats exhibited a significant enlargement of the parathyroid volume as compared with nondiabetic controls. Furthermore, karyometric determinations revealed significantly larger nuclei of the parathyroid cells in the diabetic rats. The urinary excretion of calcium and phosphorus was increased and the serum phosphorus level reduced in the diabetic rats as compared with the controls, whereas no difference between the groups was observed in the serum calcium level. In the diabetic rats, marked adrenal hyperplasia combined with thymus atrophy was demonstrated, indicating increased adrenocortical activity. The increased parathyroid volume is discussed against the background of the altered metabolism of calcium and phosphorus and the increased adrenocortical activity.

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