Synthesis of deuterium‐labelled lithocholic acid

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Abstract
A convenient synthesis is reported of lithocholic acid labelled in high isotopic purity with two atoms of deuterium at C‐11. Incorporation of deuterium is achieved by base‐catalyzed equilibration of a 12‐oxo bile acid in heavy water. The product is converted in situ into its tosylhydrazone derivative which is reduced with sodium borohydride to afford the labelled 12‐deoxy bile acid.