Heptulose Phosphate Formation in Thiamine Deficiency and Other Physiological States.

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Abstract
Summary In the rat the systems responsible for heptulose phosphate formation from sugar phosphate and nucleoside were completely developed at birth with the exception of low activity in the liver towards nucleoside. The thiamine-deficient adult rat exhibited a reduction of 50 to 95% of enzyme activity in heptulose phosphate formation in lung, spleen, intestine and pancreas. Subsequently, a supplement of thiamine HCl to the deficient animal restored the enzyme level to normal. The effect on heptulose phosphate formation was less extensive in mice made Vit. B1 deficient by feeding pyrithiamine hydrobromide than it was in rats, but there was a marked decrease in activity towards adenosine. Neither the absence of insulin nor of adrenocorticoid hormone had any effect on heptulose phosphate formation from sugar phosphate and nucleoside. In normal rat and mouse tissues 20 to 45% of heptulose phosphate was due to 3-ketoheptose phosphate, the formation of which was also depressed in Vit. B1 deficient tissue.

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