Catechol transport by the renal tubule in the chicken

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Abstract
1, 2-Dihydroxybenzene (catechol) was actively transported across the renal tubule in the direction of excretion, using the Sperber technique of unilateral renal portal infusion in hens. Attempts to relate the mechanism of catechol transport to organic acid or organic base transports were not successful. Thus it seems that the transport of catechol occurs by a pathway which is separable from organic anion and organic cation transport systems and is not dependent on substrate ionization. Catechol produced a selective inhibition of epinephrine transport, suggesting some common transport pathway for catecholamines and catechol. Catechol appeared in the urine almost entirely in the conjugated form. Conjugation of catechol must, therefore, occur in the renal cell.

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