Rabbit β-globin mRNA production in mouse L cells transformed with cloned rabbit β-globin chromosomal DNA
- 1 September 1979
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 281 (5726) , 40-46
- https://doi.org/10.1038/281040a0
Abstract
Mouse thymidine kinase-negative L cells were transformed with a cloned rabbit chromosomal β-globin gene linked to the cloned thymidine kinase gene of herpes simplex virus type 1. Most thymidine kinase-positive cell lines contained one or more copies of rabbit β-globin DNA and produced up to 2,000 copies of rabbit β-globin RNA per cell indistinguishable from its authentic counterpart. No mouse β-globin mRNA was detected.Keywords
This publication has 42 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Inhibitory effect of atropine on the isoprenaline-induced increase in vasopressin plasma concentration in ratsCellular and Molecular Life Sciences, 1979
- Mapping of early SV40-specific functions by microinjection of different early viral DNA fragmentsCell, 1978
- Translation of rabbit globin mRNA introduced by liposomes into mouse lymphocytesNature, 1978
- Evidence for translation of rabbit globin mRNA after liposomemediated insertion into a human cell lineNature, 1978
- The rabbit β-globin gene contains a large insert in the coding sequenceCell, 1977
- Globin RNA precursor molecules: Biosynthesis and processing in erythroid cellsCell, 1977
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977
- Purification of globin messenger RNA from dimethylsulfoxide-induced friend cells and detection of a putative globin messenger RNA precursorJournal of Molecular Biology, 1976
- A precursor of globin messenger RNAJournal of Molecular Biology, 1976