Structure-based discovery and in-parallel optimization of novelcompetitive inhibitors of thymidylate synthase
- 1 May 1999
- journal article
- Published by Elsevier in Chemistry & Biology
- Vol. 6 (5) , 319-331
- https://doi.org/10.1016/s1074-5521(99)80077-5
Abstract
No abstract availableKeywords
This publication has 49 references indexed in Scilit:
- Selection of Heregulin Variants Having Higher Affinity for the ErbB3 Receptor by Monovalent Phage DisplayPublished by Elsevier ,1998
- Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-β-lactamaseChemistry & Biology, 1998
- Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460): Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid SupportJournal of Medicinal Chemistry, 1998
- The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinaseChemistry & Biology, 1997
- Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin DChemistry & Biology, 1997
- Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid LibraryJournal of Medicinal Chemistry, 1994
- Structure-Based Molecular DesignAccounts of Chemical Research, 1994
- Rational design of potent sialidase-based inhibitors of influenza virus replicationNature, 1993
- Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(Arylmethyl) derivatives of 9-deazaguanineJournal of Medicinal Chemistry, 1993
- Design of enzyme inhibitors using iterative protein crystallographic analysisJournal of Medicinal Chemistry, 1991