Total synthesis of (.+-.)-N-(phenylsulfonyl)- and (.+-.)-N-(tert-butyloxycarbonyl)-CI, (.+-.)-CI-CDPI1, and (.+-.)-CI-CDPI2: CC-1065 functional analogs incorporating the parent 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (CI) left-hand subunit

This publication has 7 references indexed in Scilit:

• Synthesis of the left-hand ring of the antitumor antibiotic CC-1065 by an intramolecular carbenoid addition route. Synthesis and reactivity of 4-diazo-4,7-dihydroindol-7-ones and related compounds
  The Journal of Organic Chemistry, 1988
• Total synthesis of (.+-.)-N2-(phenylsulfonyl)-CPI, (.+-.)-CC-1065, (+)-CC-1065, ent-(-)-CC-1065, and the precise, functional agents (.+-.)-CPI-CDPI2, (+)-CPI-CDPI2, and (-)-CPI-CDPI2 [(.+-.)-(3bR*,4aS*)-, (+)-(3bR,4aS)-, and (-)-(3bS,4aR)-deoxy-CC-1065]
  Journal of the American Chemical Society, 1988
• Molecular basis for sequence-specific DNA alkylation by CC-1065
  Biochemistry, 1988
• Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065
  Journal of Medicinal Chemistry, 1988
• Studies on the total synthesis of CC-1065: preparation of a synthetic simplified 3-carbamoyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole dimer/trimer/tetramer (CDPI dimer/trimer/tetramer) and development of methodology for PDE-I dimer methyl ester formation
  The Journal of Organic Chemistry, 1987
• Intramolecular Diels-Alder reactions of 1,2-diazines: general indoline synthesis. Studies on the preparation of the central and right-hand segments of CC-1065
  The Journal of Organic Chemistry, 1984
• The structure of CC-1065, a potent antitumor agent and its binding to DNA
  Journal of the American Chemical Society, 1981