EFFECTS OF ADRAFINIL (CRL-40028) ON THE NOCTURNAL ACTIVITY OF RHESUS-MONKEYS (MACACA-MULATTA)

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  • 1 October 1985
    • journal article
    • research article
    • Vol. 16  (4) , 372-380
Abstract
The nocturnal activity of a primate was used as an evaluation criterium for a stimulating substance: adrafinil (CRL 40028). 2. Ten rhesus monkeys were placed in a controlled environment and their activity was measured, in relative time, using an ultra-sound system. The animals repeatedly received 60, 90 and 120 mg .cntdot. kg-1 adrafinil per os. 3. Globally, the dose of 60 mg .cntdot. kg-1 doubled the animals'' nocturnal activity whereas 90 and 120 mg .cntdot. kg-1 increased it fourfold, the activity level becoming practically identical to diurnal activity. 4. The effects of 60 mg .cntdot. kg-1 were only significant after the second treatment whereas doses of 90 and 120 mg .cntdot. kg-1 were already significantly efficient after the first administration. 5. A stimulating effect persisted approximately 36 hrs after the second treatment with 90 or 120 mg .cntdot. kg-1. No sedative effect of recovery was observed during the post-treatment phase.