Involvement of CD8+ T Cells in Delayed-type Hypersensitivity Responses against Bovine Leukemia Virus (BLV) Induced in Sheep Vaccinated with Recombinant Vaccinia Virus Expressing BLV Envelope Glycoprotein

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Abstract
Delayed-type hypersensitivity responses against bovine leukemia virus (BLV) envelope glycoprotein (gp60) were induced in the skin of sheep vaccinated with recombinant vaccinia virus (RVV) expressing BLV glycoprotein. The lesions were characterized by marked infiltration of lymphocytes, slight migration of neutrophils, eosinophils, and macrophages in the dermis to hypodermis, and partial intercellular edema in the reticular layer. Immunohistochemical analysis with monoclonal antibodies demonstrated that the lymphocytic infiltrates consisted mainly of CD8+ T cells (53.7–55.8% at 48 hours post-challenge of BLV), CD4+ T cells (24.7–26.7%), and B cells (11.5–16.9%). The role of CD4+ and CD8+ T cells in suppressing BLV growth in RVV-vaccinated animals is discussed.

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