Pharmacokinetics of cefoperazone in patients undergoing chronic ambulatory peritoneal dialysis: Clinical and pathophysiological implications
- 1 January 1984
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 26 (5) , 609-612
- https://doi.org/10.1007/bf00543494
Abstract
The pharmacokinetics of cefoperazone after i.p. and/or i.v. administration were studied in 12 CAPD patients. After i.v. injection, the plasma half-life was 2.65±0.4 h, the total clearance amounting to 70.1±19.2 ml/min. Peritoneal clearance was calculated to be 6.9±1 ml/min. After peritoneal instillation, the bioavailability was 63.9±5%. After repeated i.p. administration, no accumulation of the drug in the body was observed. Thus, cefoperazone can be safely administered for the treatment of peritonitis in CAPD patients.This publication has 3 references indexed in Scilit:
- Intraperitoneal (125I) insulin absorption during intermittent and continuous peritoneal dialysisKidney International, 1983
- Noncompartmental Determination of the Steady‐State Volume of DistributionJournal of Pharmaceutical Sciences, 1979
- Pharmacokinetics of Ampicillin, Cephalothin and Doxycycline in Various Tissues of the RatChemotherapy, 1976