Antibodies to Hepatitis B Surface Antigen as the Sole Hepatitis B Marker in Hospital Personnel

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Abstract
The epidemiologic and serologic differences between hospital employees with antibodies to hepatitis B surface antigen (anti-HBs) alone or in combination with antibodies to hepatitis B core antigen (anti-HBc) were evaluated. Of 105 employees with anti-HBs, 38 (36%) did not have anti-HBc. Sera from employees with anti-HBs alone had significantly lower mean sample ratio units of anti-HBs than srea with both antibodies (15.9 .+-. 43.2 vs. 110.3 .+-. 73.9, P < 0.0005) and more commonly had < 10 sample ratio units of anti-HBs (32 [84%] of 38 vs. 9 [13%] of 67, P = 0.0001). The anti-HBs in sera with anti-HBs alone was predominantly IgM as shown by inactivation with 2-mercaptoethanol and the presence of anti-HBs activity in serum IgM fractions. Failure of protection from hepatitis B virus infection in persons with anti-HBs aone and the presence of nonprotective IgM anti-HBs in chimpanzees was reported. The use of anti-HBs as a single serologic screening test for hepatitis B virus immunization programs evidently may not be reliable in identifying employees with protective antibodies.