A new family with fra(10)(q25): Spontaneous expression and 100% expression with 100 μM BrdU

31 July 1985

journal article
research article
Published by Wiley in American Journal of Medical Genetics

Vol. 21 (4) , 643-648
https://doi.org/10.1002/ajmg.1320210405

Abstract

We report on a family with fra(10)(q25) ascertained through a female with multiple minor anomalies and present in her phenotypically normal father and other family members. The site is expressed spontaneously at levels of 9% in lymphocytes, 2% in lymphoblasts, and 6% in skin fibroblasts. Expression frequency is significantly enhanced to levels as high as 100% by addition of BrdU to the culture medium. The consistently high level of induced expression in lymphoblasts from the proband facilitates analysis of the biochemical and structural bases of fragile site expression.

Keywords

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