The Uptake and Metabolism of Noradrenaline in the Isolated Heart of Spontaneously Hypertensive Rat

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Abstract
Isolated hearts of spontaneously hypertensive rats (SHR) were perfused with 3 × 10–7M3 H-d,l-noradrenaline. After 5–40-minute perfusion the amounts of noradrenaline and its acidic and neutral metabolites in the heart were assayed with column ion exchange chromatography. The total accumulation of noradrenaline and its metabolites into the hearts of the SH rats and of the control rats were about similar. An almost equal amount of accumulated noradrenaline was metabolized in the hearts of both groups of rats. However, in all perfusion periods studied in the SH rats the relative amount of acidic metabolites was 25–55 % lower and that of neutral metabolites 36–78 % higher than the corresponding values in the normotensive rats.

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