Comparison of Oxygen Poisoning of the Lung in Cyanotic and Acyanotic Dogs

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Abstract
Cyanosis was produced in dogs by the surgical creation of large intracardiac venoarterial shunts. Eight cyanotic and 10 acyanotic dogs were exposed, awake and unrestricted, to 1 atmosphere of 98 per cent to 100 per cent oxygen for two days. In each of the two groups of animals, a similar frequency and extent of pulmonary oxygen damage was found, as judged by the production of respiratory distress, atelectasis, alveolar edema and hemorrhage and abnormal surface tension of whole-lung extracts. Cyanosis did not protect against pulmonary injury from 100 per cent oxygen at 1 atmosphere for two days.

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