A novel dodecadepsipeptide, cereulide, is an emetic toxin of
- 1 June 1995
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 129 (1) , 17-19
- https://doi.org/10.1016/0378-1097(95)00119-p
Abstract
A vacuole-formation substance, cereulide of Bacillus cereus, is an emetic toxin in animals. Both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in Suncus murinus, a new animal model of emesis. Vagotomy or a 5-HT3 receptor antagonist completely abolished this emetic effect. Therefore, cereulide causes emesis through the 5-HT3 receptor and stimulation of the vagus afferent. We also found that our purified cereulide caused swelling of mitochondria of HEp-2 cells.Keywords
This publication has 0 references indexed in Scilit: