Experiments on the ‘Overgrowth’ Phenomenon in the Brain of Chick Embryos

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Abstract
A pathologic phenomenon consisting of complex folding of the brain-wall has been obtained in living chick embryos after operations upon the rhombencephalon in early stages. The operation consisted of the extirpation of the tip of the notochord and the overlying neuromere. Its results mainly appear in the hemispheres and tectum opticum region, but sometimes also extend to other evaginated brain parts, viz. the optic évaginations, the epiphyseal region, and possibly also the caudal parts of the hypothalamus. The pathologic phenomenon is identical with certain abnormal foldings, described in human embryonic brains by Patten (1952) and called by him ‘overgrowth’. It may be combined with encephaloschisis in the mesencephalic roof.