STUDIES ON THE METABOLISM OF THE TREPONEMATA II
- 1 March 1956
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 71 (3) , 274-277
- https://doi.org/10.1128/jb.71.3.274-277.1956
Abstract
Whole cells and sonic extracts of the Reiter treponeme catalyze transamination reactions involving a number of amino acids and keto analogues. The formation of glutamic acid, aspartic acid and alanine were demonstrated from their respective keto analogues by transamination. Glycine formation was also demonstrated by transamination with glyoxylic acid, and was found to be one of the most active systems studied. Transamination reactions between glutamine and alpha-keto acids are described. Pyridoxal phosphate appears to be the coenzyme for the treponemal transamination. Inhibition of transamination by bromosulfalein was studied and a possible mechanism of this inhibition presented.Keywords
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