HETEROLOGOUS TUMOUR GROWTH PATTERNS INDUCED IN RELATED MHC - DEFINED CHICKEN LINES BY SEPARATE ISOLATES OF AN AVIAN SARCOMA VIRUS STRAIN

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Abstract
Different patterns of tumor growth resulted from inoculation of separate isolates of the subgroup C Bratislava 77 strain (B77) of avian sarcoma virus (ASV) into 3 closely-related inbred lines of chickens. The major genetic difference between these chicken lines is that each is homozygous for a different MHC (major histocompatibility complex) haplotype. For one of the viral isolates, resistance to progressive tumor growth is controlled by MHC-linked genes. MHC-controlled tumor rejection apparently operates on viral or cellular determinants different from those which define classical viral group or subgroup specificity.