BETA-ADRENERGIC RECEPTORS IN RAT-KIDNEY - DIRECT LOCALIZATION BY A FLUORESCENT BETA-BLOCKER

  • 1 January 1977
    • journal article
    • research article
    • Vol. 36  (5) , 465-468
Abstract
A new fluorescent .beta.-adrenergic blocker, 9-amino-acridin propranolol (9-AAP), was administered i.v. to albino rats. Fluorescent aggregates of 9-AAP binding sites were concentrated in the vascular poles of the glomeruli in association with the preglomerular afferent arterioles. 9-AAP fluorescence was reduced following pretreatment with (.+-.)- and (-)-propranolol and was less affected in rats pretreated by the (+)-racemic isomer. 9-AAP binding sites were also observed on the lining epithelium of the renal collecting system. 9-AAP may label .beta.-adrenergic receptors in rat kidney.