Metabolic transients: hypoxic and oxygenated rabbit aorta with and without substrate

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Abstract
Hypoxic and oxygenated rabbit aortic rings, with and without substrate, were tested for their response to O2, glucose and epinephrine. Hypoxic tissue with glucose responded to O2 pulses and epinephrine for many hours. The initial response to O2 pulses of hypoxic substrate-deprived tissues, was predominantly relaxatory. These tissues soon failed to respond to O2 pulses or drugs; even at this time, the restoration of glucose or O2 to the bathing fluid often produced at least a partial recovery. Oxygenated tissues with glucose continued for long periods to give large contractions when tested with epinephrine; similar tissues without glucose showed a progressive decline in the magnitude of drug responses. The addition of glucose to glucose-free oxygenated rings caused contraction similar to that seen with hypoxic substrate-free tissue. The relative effects of O2 and glucose on relaxation and contraction are discussed.

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