Inhibition of histamine methylation in vivo by the Dimaprit analog, SKF compound 91488
- 1 December 1979
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 9 (5-6) , 455-460
- https://doi.org/10.1007/bf01968110
Abstract
The Dimaprit analog,S-[4-(N,N-dimethylamino)-butyl]isothiourea (SKF Compound 91488), which is a noncompetitive inhibitor (K i, 0.9 μM) of histamine-N-methyl-transferase in vitro, inhibited the methylation of labeled histamine in mice. When administered in combination with the diamine oxidase inhibitor, aminoguanidine, an almost complete block of histamine metabolism was observed. The inhibition was dependent on dose of drug and was apparent with doses of 50 mg/kg and greater. Since Compound 91488 is reported to have no agonist activity of its own, the drug may help to identify the actions of histamine released from endogenous stores in response to physiological and pathological stimuli.This publication has 37 references indexed in Scilit:
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