GENETIC STUDY OF IMMUNOGLOBULIN-E

  • 1 January 1978
    • journal article
    • research article
    • Vol. 30  (1) , 46-58
Abstract
Path analysis of families gives evidence of genetic heritability (.425) for serum Ig[immunoglobulin]E levels. Complex segregation analysis indicates, in addition to significant polygenic heritability, a major regulatory locus RE, with homozygotes re/re maintaining persistently high levels of IgE. The gene frequency of re is .489, and the displacement is 1.67 standard deviations.