Synthesis of [3,5-3H2-Tyr23]-β-corticotrophin-(1–24)-tetracosapeptide
- 1 January 1973
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 2875-2879
- https://doi.org/10.1039/p19730002875
Abstract
The synthesis is described of β-corticotrophin-(1–24)-tetracosapeptide labelled with tritium in the tyrosine residue at position 23 to a specific radioactivity of 46 Ci mmol–1 by reductive deiodination of a protected precursor. Evidence for the integrity of the final product is provided by amino-acid analysis, column and thin-layer chromatography, and bioassay, supported by chemical and enzymic analytical data on the protected precursor and the derived tetracosapeptide containing di-iodotyrosine.Keywords
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