ON THE COAGULATION DEFECT IN PEPTONE SHOCK

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Abstract
When the clotting times of plasma obtained 5, 30, and 60 min. after the injection of peptone into a dog are plotted against progressive dilutions of thrombin, a characteristic set of curves are obtained. A similar series of curves are found when the clotting times of plasma obtained after the intraven. injection of peptone are plotted against the same dilutions of thrombin; suggesting that the incoagulability of peptone plasma is due to the formation of heparin or a heparin-like substance. The direct linear relationship between the clotting time of normal plasma and the concn. of thrombin demonstrates that the normal antithrombin of the blood does not interfere with coagulation, whereas the antithrombin produced by heparin has a marked inhibitory action. It is postulated that the heparin-antithrombin (possibly a heparin-protein compound) has a greater affinity for thrombin than fibrinogen has and thus promptly combines with thrombin and so inactivates it before it can react with fibrinogen.

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