Effectiveness of pilocarpine in postradiation xerostomia
- 15 March 1987
- Vol. 59 (6) , 1123-1125
- https://doi.org/10.1002/1097-0142(19870315)59:6<1123::aid-cncr2820590614>3.0.co;2-x
Abstract
Pilocarpine and placebo tablets were administered for 90 day periods in a double-blind, sequential crossover trial to 12 patients with postradiation xerostomia. Salivary flow was measured by two techniques, symptomatic change and adverse side effects were also recorded. Nine of the 12 patients showed marked improvement by two or more criteria while taking pilocarpine. None of the 12 patients showed meaningful improvement while on placebo. Side effects were minimal and easily controlled. These results show that pilocarpine is effective in relieving the signs and symptoms of postradiation xerostomia. Cancer 59:1123-1125, 1987.This publication has 7 references indexed in Scilit:
- Pilocarpine for the treatment of xerostomia associated with salivary gland dysfunctionOral Surgery, Oral Medicine, Oral Pathology, 1986
- Radiosensitivity of the Human Parotid GlandExperimental Biology and Medicine, 1978
- A saliva substitute for use by xerostomic patients undergoing radiotherapy to the head and neckOral Surgery, Oral Medicine, Oral Pathology, 1977
- Effect of Radiotherapy on Whole Saliva FlowJournal of Dental Research, 1977
- Prevention of Xerostomia-Related Dental Caries in Irradiated Cancer PatientsJournal of Dental Research, 1977
- The oral component of Sjögren's syndromeOral Surgery, Oral Medicine, Oral Pathology, 1975
- The Effect of Irradiation in High Doses on Parotid GlandsActa Oto-Laryngologica, 1971