Acute bronchoconstriction caused by Beclovent and not Vanceril

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Abstract
A 24 yr old asthmatic patient reported acute wheezing immediately after using an aerosol of beclomethasone dipropionate (Beclovent). She was hospitalized for bronchial challenges. Immediate bronchoconstriction was shown after 2 puffs of this aerosol and after inhalation of the placebo containing all products of the aerosol less the beclomethasone. Another brand of beclomethasone aerosol, Vanceril, produced no reaction. Since the contents of these 2 beclomethasone aerosols are similar, the rubber or plastic derivative(s) present in the metering valve might have been responsible for the reaction.