Histological and Molecular Analysis of Cottontail Rabbit Papillomavirus-Induced Papillomas Treated With Hematoporphyrin Derivative Photodynamic Therapy
- 1 February 1988
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 114 (2) , 175-178
- https://doi.org/10.1001/archotol.1988.01860140073024
Abstract
• The clinical regression of cottontail rabbit papillomavirus-induced cutaneous papillomas on Dutch-belted rabbits following treatment with hematoporphyrin derivative photodynamic therapy was recently reported. Those papillomas that underwent total regression failed to recur at 18 months. Tissues from totally regressed papillomas and adjacent sites failed to reveal the presence of papilloma on histological examination. These findings were confirmed by the absence of viral DNA following analysis by Southern blots for cottontail rabbit papillomavirus viral copy number and DNA restriction pattern. Partially regressed papillomas and untreated papillomas revealed histologically typical papillary features with approximately equal amounts of viral DNA. (Arch Otolaryngol Head Neck Surg1988;114:175-178)This publication has 5 references indexed in Scilit:
- Hematoporphyrin Derivative Therapy of Papillomas: Experimental StudyJAMA Otolaryngology–Head & Neck Surgery, 1986
- Photodynamic Therapy in Head and Neck CancerJAMA Otolaryngology–Head & Neck Surgery, 1985
- The simultaneous extraction of high-molecular-weight DNA and of RNA from solid tumorsAnalytical Biochemistry, 1983
- Photoradiation Therapy for Cutaneous and Subcutaneous MalignanciesJournal of Investigative Dermatology, 1981
- PHOTORADIATION THERAPY FOR TREATMENT OF MALIGNANT-TUMORS1978