Synthesis and Cytostatic Activity of Halomethylthiazole C-Nucleosides and Analogues1
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 1 (2) , 127-138
- https://doi.org/10.1080/07328318208078827
Abstract
The synthesis of 2-(β-D-ribofuranosyl)-and 2-(tetrahydropyran-2-yl)-4-halomethylthiazoles from 2, 5-anhydro-D-allonthioamide and tetrahydropyran-2-thiocarboxamide is described. Bromination of 2-(β-D-ribofuranosyl)- and 2-tetrahydropyran-2-yl)-4-methylthiazole with NBS is studied. Cytostatic activity against HeLa cells of all the compounds is reported.This publication has 8 references indexed in Scilit:
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