Vincristine Therapy of Idiopathic and Secondary Thrombocytopenias

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Abstract
Idiopathic thrombocytopenia refractory to glucocorticoids and splenectomy remains a serious problem. Prompt benefit was obtained from vincristine in six of seven patients not splenectomized who were refractory to glucocorticoids and in nine of 13 patients refractory to both glucocorticoids and splenectomy. Five of the nine were also refractory to cyclophosphamide or azathioprine or both.