INVITRO EFFECTS OF FRUCTOSE-1,6-DIPHOSPHATE ON OXYGEN-AFFINITY AND ELECTROLYTE EQUILIBRIUM IN HUMAN-BLOOD

  • 1 January 1983
    • journal article
    • research article
    • Vol. 42  (2) , 281-292
Abstract
The in vitro effects of a solution of fructose-1,6-diphosphate on Hb-O2 affinity [P50] and electrolyte distribution between plasma and red cells were evaluated. Fructose-1,6-diphosphate increased intracellular pH and decreased extracellular pH. There were no shifts in Na+, K+, Ca2+ and Cl- between plasma and red cells. Red cell content of 2,3-diphosphoglycerate remained unchanged, while P50 was reduced (as a consequence of the intracellular alkalosis). The therapeutic implications of these results are discussed.