The site of action potential initiation in cerebellar Purkinje neurons
- 23 January 2005
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 8 (2) , 137-139
- https://doi.org/10.1038/nn1390
Abstract
Knowledge of the site of action potential initiation is essential for understanding how synaptic input is converted into neuronal output. Previous studies have shown that the lowest-threshold site for initiation of action potentials is in the axon. Here we use recordings from visualized rat cerebellar Purkinje cell axons to localize the site of initiation to a well-defined anatomical structure: the first node of Ranvier, which normally forms at the first axonal branch point.Keywords
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