The involvement of ?- and ?- but not ?-opioid receptors in the body weight gain of suckling rats

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Abstract
The effects of the benzomorphan antagonist Mr 2266 and the selective δ-antagonist ICI 154,129 on the body weight gain of 6-day-old suckling rat pups was observed. Mr 2266 significantly reduced body weight gain in these animals, though ICI 154,129 had no affect on this variable. These findings suggest that μ- and κ- but probably not δ-opioic receptors are involved in the regulation of ingestive behaviours in infant rats. The results are discussed in relation to the development of opioid-receptor subtypes in the neonatal rat brain.